IndraLab

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OTUD5 decreases the amount of SYNM. 3 / 3
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"Mechanically, we found that OTUD5 deficiency further reduced endogenous K63‐linked polyubiquitination of α‐Syn and upregulated its protein level, then promoted the formation of pathologic p‐α‐Syn and aggravated the pathogenic consequences induced by α‐Syn PFF.In summary, we demonstrated that OTUD5 negatively regulated α‐Syn protein levels by promoting endolysosomal degradation independent of its deubiquitinate activity."
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"Consistently, knockdown of OTUD5 significantly enhanced α‐Syn protein expression in SH‐SY5Y cells (Figure 1C), while the mRNA levels remained unaffected (Figure 1D)."
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"Additionally, OTUD5 deficiency significantly enhanced α‐Syn protein levels in primary cultured midbrain neurons (Figure 1E)."
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