IndraLab

Statements

Lipopolysaccharide increases the amount of TNFAIP3. 10 / 10
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"The effect of HM to synergistically enhance LPS-induced NFKBIA and TNFAIP3 expression suggests that, despite an initial upregulation of inflammatory cytokines (in the case of proinflammatory LPS, P-LPS), there is a negative feedback loop causing suppression of NF-κB as well as its associated induction of inflammation in gut epithelial cells."
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"We have proposed a working model based on these results (XREF_FIG) and suggest that Tnfaip3 might be expressed through transcriptional regulation of both p65 and the p38-downstream transcription factor C/EBPbeta in response to LPS."
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"LPS upregulated TNFAIP3 expression, as determined by ELISA, significantly more than Pam3CsK4, which induced only a slight increase in TNFAIP3 levels (Figure 3a)."
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"LPS significantly enhanced TNFAIP3 and IRAK-M levels but reduced Sp1 levels."
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"Circle heatmap analysis showed that LPS markedly elevated the expression levels of Serpinb2, Cd40, Nfkb2, Tnfaip3, Cebpb, Junb, Socs3, Tnf, Il6, Cd14, Il1b, Nfkbia, Tnfrsf1b, Il1rn, and Il36a in the inflammation-related pathways (Figure 6G)."
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"Ex vivo farm dust or LPS stimulation restored TNFAIP3 expression to healthy levels in asthmatics and shifted NF-kappaB signaling associated gene expression towards an anti-inflammatory state (p < 0.001)."
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"In the TREM2 + ScMglia population, expression of IL-1beta, CCL2, and TNFAIP3 were all significantly induced by LPS stimulation compared with untreated controls (XREF_FIG)."
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"Similar to our RNAseq data, HM significantly enhanced LPS-induced IL8, CXCL2, CCL20, CXCL1, NFKBIA, TNFAIP3, and ZFP36 expression compared to LPS alone, whereas HM alone had minimal effect (Fig. 2b-h)."
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"In this study, LJF significantly inhibited the LPS stimulated downregulation of CXCL2, CXCL1, CXCL6, NFKBIA, IFNG, IL6, IL17A, IL17F, IL17C, MMP9, and TNFAIP3 mRNA expression in lung tissue homogenates according to RNA-Seq and qRT-PCR, which indicates that the IL-17 signalling pathway is critical for treatment by LJF of LPS induced ALI."
| PMC
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"Whereas LPS or TNF treatment induced the expression of Tnf, Tnfaip3 and Nfkiab mRNAs, we did not detect upregulation of these genes following ZBP1 or ZBP1ca expression."
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