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Statements

USP26 activates AR. 2 / 2
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"In LNCaP cells, Usp26 depletion by siRNA enhances AR dependent transcription, suggesting it acts on a factor that is negatively regulated by ubiquitination (Dirac and Bernards, 2010)."
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"The AR signaling in the testis is essential for spermatogenesis.34 Substrates of USP26 include AR, MDM2 proto-oncogene (MDM2), SMAD family member 7 (SMAD7), and protein regulator of cytokinesis 1 (PRC1).35 Because USP26 can prevent the degradation of AR, the downregulation of USP26 may affect spermatogenesis.35However, the role of USP26 in male infertility remains doubtful because USP26-knockout mice are reported to be fertile.36 Nevertheless, the function of USP26 might be different between humans and mice."
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