IndraLab

Statements

CYLD activates Ubiquitin. 7 / 7
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"Similarly, following CYLD-mediated cleavage of K63 ubiquitin chains, MIB2 catalyzes K48 ubiquitin chains on CYLD for degradation, thus completely terminating the CYLD activity.50 Altogether, while CYLD initially functions as a bridging and adaptor protein for signal progression independent of its DUB activity, it eventually terminates signaling by supporting the degradation of key molecules, including itself through its DUB activity (Figure 6)."
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"This step is likely proceeded by the removal of Complex I K63/M1 ubiquitin chains mediated by CYLD, which is recruited into the complex through LUBAC component HOIP (47, 48)."
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"MiR-182 can suppress cylindromatosis (CYLD), a deubiquitinase that mediates ubiquitin deconjugation and acts as an inhibitor of nuclear factor kappaB (NF-kappaB) activation, leading to overactivation of NF-kappaB signaling."
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"MALT1 has also been reported to cleave several other Ub signaling-related factors, including CYLD and A20, and thereby might regulate the disassembly of Met1-Ub ( Demeyer et al., 2016 )."
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"However, the results pertaining to K48-linked ubiquitin deconjugation mediated by CYLD were not consistent with those of a previous study [ 20 ] reporting that CYLD exhibits minimal activity against K[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, CYLD mediated removal of ubiquitin chains, including of linear chains, from components of the TNF-RSC results in diminished TNF induced gene activation and, at the same time, enhanced cell death."
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