IndraLab

Statements

CYLD activates Ubiquitin. 4 / 4
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
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"MiR-182 can suppress cylindromatosis (CYLD), a deubiquitinase that mediates ubiquitin deconjugation and acts as an inhibitor of nuclear factor kappaB (NF-kappaB) activation, leading to overactivation of NF-kappaB signaling."
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"Thus, CYLD mediated removal of ubiquitin chains, including of linear chains, from components of the TNF-RSC results in diminished TNF induced gene activation and, at the same time, enhanced cell death."
26670046
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"Both CYLD and TRAF2 phosphorylation thus increase ubiquitin-dependent NF-κB signaling."
23333767