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USP28 activates epithelial to mesenchymal transition. 2 / 2

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"Through the miR‐500a‐5p/ubiquitin specific peptidase 28 (USP28) axis, exosomal miR‐500a‐5p in CAFs could promote cancer cell proliferation, EMT, and metastasis [57]."

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"Pard3 deletion led to the up-regulation of USP28, which promoted BC migration and migration via Snail1 stabilization.Given its essential role in tumor metastasis and EMT, Snail1 is considered a key regulator of aggressive phenotypes in tumors."

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IndraLab

Statements

USP28 activates epithelial to mesenchymal transition. 2 / 2

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