IndraLab

Statements

Calcium(2+) activates CACNA1C. 7 / 8
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"Han et al. found that even apoCaM and the Ca -insensitive mutant CaM can induce inactivation of Cav1.2 channels at high concentrations, referred to as “CaM-dependent inhibition” [51]."
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"Timothy Syndrome, a disorder encompassing multiple dysfunctions including autistic phenotypes, can be caused by a mutation in Ca V 1.2 (CACNA1C), which increases the open times of VSCCs."
19376067
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"L-type calcium channel (LTCC) is an important route of calcium influx which also regulates intracellular calcium level.71 Fluoride up-regulates LTCC Cav1.2 in renal cells; thus, enhancing extracellular calcium uptake and leading to calcium overload within the cells."
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"The expression of functionally different splice isoforms of Ca V 1.2 and Ca V 1.3 in different tissues enables Cacna1c and Cacna1d genes to support a wider range of calcium dependent cellular functions [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"Interestingly, deletion of ANO1 strongly inhibited the receptor stimulated Ca 2+ oscillations and contraction, but not contraction induced by membrane depolarization and Ca 2+ influx through CaV1.2."
38701708
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"Fig. 3 D illustrates that classic L-type Ca ++ channel blockers such as diltiazem and verapamil block Cav1.2 by approximately 20% or more at free plasma C max ."
27060526
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"These occurred mainly in genes that are expressed in synapses of both excitatory and inhibitory neurons.Several risk genes encode voltage-gated calcium and chloride channels known to modulate glutamate receptor activity (CACNA1C and CLCN3), metabotropic receptors (glutamate (GRM1) and GABA (GABBR2)), and the NMDA-R subunit (GRIN2A)."
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