IndraLab

Statements

Gallic acid inhibits MAPK8. 4 / 4
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"In this study, we found that GA pretreatment could sharply suppress hepatic HMGB1 expression, p-IRAK1, p-JNK, p-ERK, p-p38, and p-IκB levels induced by APAP."
28668488
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"This is in consistence with the reports that resveratrol has protective effect in the models of β-amyloid- or gallic acid-induced PC12 cells through blocking p-JNK (Jang and Surh 2003; Kang et al. 2009), and Erk1/2 pathway inhibitor U0126, but not p38 inhibitor SB203580, mimicks the inhibitory action of resveratrol on glutamate-induced neuronal cell death (Cho et al. 2014)."
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"Similar to the DMSO control, GA exhibited almost no effect on TNF induced JNK1 activation, even though the unstimulated JNK1 activity was slightly reduced by GA treatment."
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"GA can induce differentiation, repress stemness by targeting JNK1, and enhance the antitumor effect of sorafenib in HCC."
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