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USP10 inhibits Neoplasm Invasiveness. 19 / 19
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"However , in lung cancer , USP10 can inhibit cell growth and invasion by stabilizing PTEN , suggesting that the roles of USP10 in the different cancer types are distinct [ 51 ] ."
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"Moreover, USP10 inhibited cell growth and invasion in lung cancer [XREF_BIBR], and was an independent factor for the prognosis of gastric carcinoma [XREF_BIBR]."
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"The results indicated that USP10 downregulation in U2‐OS and 143B cells reduced their migration and invasiveness abilities (Figure 2C,E)."
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"Furthermore , USP10 can also interact with and deubiquitinate PTEN , USP10 inhibition stimulates tumor growth and invasion , but this effect can be abolished by reinserting PTEN ( Sun et al ., 2018 ) ."
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"USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN."
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"CAPRIN-1 enhances proliferation [ 71,72,73 ] , whereas USP10 inhibits tumor progression and invasion [ 74,75 ] ."
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"Furthermore, USP10 inhibited lung cancer cell growth and invasion by upregulating PTEN ."
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"Overexpressing USP10 inhibited invasion, migration, and EMT properties of FTC133-DOX cells and promoted apoptosis."
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"Sun et al. 2018 confirmed that USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN (Sun et al. 2018)."
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"Molecular mechanism studies showed that USP10 inhibited the epithelial-mesenchymal transition (EMT) process by increasing the stability of TNFRSF10B protein, thereby regulating the migration and invasion of GC cells."
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"For example , USP10 inhibits lung cancer cell growth and invasion ."
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"To further verify that USP10 inhibited the migration and invasion of GC cells, we constructed overexpressed plasmid GV657-USP10."
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"Furthermore, USP10 can also interact with and deubiquitinate PTEN, USP10 inhibition stimulates tumor growth and invasion, but this effect can be abolished by reinserting PTEN (Sun et al., 2018)."
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"In this study, we also found that overexpression of USP10 inhibited invasion, migration, and EMT properties of DOX-resistant thyroid cancer cells."
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"In the present study, the experimental results obtained from in vitro cell models showed that downregulated USP10 significantly promoted GC cell migration and invasion, while upregulated USP10 significantly inhibited GC cell migration and invasion."
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"7 Likewise, by binding and deubiquitylating Pten, USP10 inhibited the growth and invasion of lung cancer cells."
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"For example, USP10 inhibits lung cancer cell growth and invasion."
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"Our study established a high-throughput strategy for screening de-ubiquitination targets for USP10 in GC metastasis, and found that USP10 inhibited the migration and invasion of GC cells through suppressing EMT due to de-ubiquitination of TNFRSF10B."
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"USP10 suppresses lung cancer cell invasion and growth via upregulating PTEN [22]."
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