IndraLab

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BRCC3 binds USP15. 2 / 2
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"Initially, we sought to establish the direct interaction between endogenous BRCC3 and USP15 in J82 cells through Co-IP experiments."
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"Subsequently, through a series of comprehensive gain and loss-of-function experiments, we have reaffirmed the positive correlation between BRCC3 protein expression and USP15, confirming the pivotal role of USP15 in modulating the multiplication, invasiveness, and migration of bladder cancer by regulating BRCC3 expression.Subsequently, to assess the interaction between USP15 and BRCC3, we conducted meticulous Co-IP experiments, conclusively demonstrating direct binding between the two proteins."
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