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OTUD3 deubiquitinates YY1. 5 / 5
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"OTUD3 deubiquitinates YY1."
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"Conversely, over-expression of wild-type OTUD3 dose-dependently suppressed YY1 polyubiquitination in DLD1 cells and HEK-293T cells (Fig. 3A, B)."
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"Moreover, consistent with these findings, up-regulation of PLK1 promoted the deubiquitination of YY1 by OTUD3 (wild-type), while OTUD3-S326A weakened the deubiquitination of YY1, compared to OTUD3(wild-type) (Fig. 5S, T)."
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"In this study, we found that OTUD3 can promote YY1 protein deubiquitination and stabilization."
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"Furthermore, PLK1 mediates OTUD3 S326 phosphorylation, which further enhances OTUD3 binding and deubiquitination of YY1."
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