IndraLab

Statements

USP15 activates TBX3. 5 / 5
| 5
reach
"Consequently, USP15 deficiency inhibits melanoma tumor cell proliferation and xenografted tumor growth in the TBX3-dependent manner, which is consistent with reported USP15 function in melanoma development (Fig. 5h, Supplementary Fig. 4d, e)."
38750011
reach
"This stabilization of TBX3 depends on USP15’s DUB activity, since wild-type USP15, but not the USP15 mutant, restored TBX3 loss caused by USP15 depletion (Fig. 1g, h), and ectopic USP15 lost the function to prolong TBX3 half-life (Fig. 1i, Supplementary Fig. 1e, f)."
38750011
reach
"To further evaluate the clinical significance of USP15 mediated TBX3 homeostasis and understand their correlation in tumorigenesis, we performed immuno-histochemical (IHC) staining to examine the expression of these factors in patient samples."
38750011
reach
"Therefore, we asked whether USP15-mediated TBX3 stabilization could be a molecular signature-related event."
38750011
reach
"Activated BRAF/MAPK pathway functions partially through USP15-mediated TBX3 stabilization, thus genetic knockout of Usp15 leads to disrupted organ development and tumorigenesis comparable to Tbx3 mutants."
38750011