IndraLab

Statements

CYLD inhibits cell growth. 10 / 10
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"Loss of CYLD in HMCLs was found to enhance β-catenin stabilization and localization to the nucleus, increase β-catenin-LEF/TCF reporter activity, and enhance MM cell growth and survival."
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"In the present study, CYLD overexpression inhibited cell growth and promoted cell apoptosis in colon cancer cells, while the expression levels of p-p65 and p65 were decreased and those of p-IkappaBalpha and IkappaBalpha were increased."
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"CYLD negatively regulates the cell cycle by controlling cell growth and division at the G(1)/S-phase and cytokinesis by associating with alpha-tubulin and microtubules through its CAP-Gly domains ."
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"CYLD inhibits cervical cancer cell growth, survival, invasion, and migration."
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"Expression of the N-terminal CYLD fragment did not affect cell growth, while expression of the C-terminal CYLD fragment did reduce cell growth, albeit in LY10 to a lesser extent than expression of full-length CYLD."
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"Exogenous expression of CYLD inhibited melanoma cell growth and migration in vitro."
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"miR-362 targeted cylindromatosis (CYLD) activation of the NF-kappaB pathway induced cell growth and apoptosis tolerance in gastric cancer."
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"We confirmed that CYLD suppressed NPC cell growth and proliferation, as evidenced by decreased CCK-8 OD value and EDU-positive ratio, indicating that CYLD functioned as a tumor suppressor ( Supplement[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD represses cell growth and NF-kappaB activity."
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"Taken together, our data revealed that (1) CYLD is cleaved by MALT1, (2) these MALT1-mediated cleavage products of CYLD undergo rapid proteasomal degradation (inactivation), and (3) CYLD represses NF-κB activity and cell growth; hence, MALT-mediated cleavage of CYLD promotes NF-κB activity and growth of aggressive B-cell receptor-dependent lymphomas."
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