IndraLab

Statements

Benzyl isothiocyanate inhibits UCHL5. 6 / 6
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reach
"BITC and PEITC inhibit USP9x and UCH37."
26542215
reach
"BITC and PEITC inhibit USP9x and UCH37 in vitro."
26542215
reach
"Here we report that both BITC and PEITC inhibit USP9X and UCH37 and other DUBs at physiologically relevant concentrations and time scales."
26542215
reach
"Docking results suggest that benzyl isothiocyanate, phenethyl isothiocyanate, and DL-sulforaphane are more potent inhibitors of UCHL5 than USP14, and these ITCs could interact with the catalytic triads of UCHL5 and USP14."
30015387
reach
"Both PEITC and BITC inhibited UCH37 with values of EC 50 of 36 +/- 5 muM and 31 +/- 6 muM, in reasonable agreement with the lysate assays (XREF_FIG and XREF_SUPPLEMENTARY)."
26542215
sparser
"We observed a dose-dependent inhibition of UCHL5 by BITC ( xref , lower panel , lanes 3–5 vs ."
30015387