IndraLab

Statements

UCHL1 increases the amount of ERK. 3 / 3
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"Our results showed that consistent with the trend of P-mTOR, cPKCgamma knockout significantly decreased the ERK phosphorylation following 1-hr OGD/24-hr R, while UCHL1 shRNAs obviously enhanced the level of P-ERK."
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"UCHL1 shRNA 2 and 3 treatments could significantly enhance the level of P-ERK, which was consistent with the change of P-mTOR."
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"75 Simultaneously, studies have shown that LDN‐57444, an inhibitor of UCHL1, could regulate oxidative stress, and mitochondrial function and reduce ERK1/2 expression, thereby inhibiting mouse oocytes' maturation."
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