IndraLab

Statements

HULC activates USP22. 4 / 4
| 4
reach
"HULC upregulated ubiquitin specific peptidase 22 (USP22), leading to the decrease of ubiquitin mediated degradation of Sirt1 protein by removing the conjugated polyubiquitin chains from Sirt1 [XREF_BIBR]."
32351584
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"XREF_BIBR Similarly, HULC is able to stabilize silent information regulator 1 (Sirt1) protein in hepatocellular carcinoma cells because HULC can upregulate ubiquitin specific peptidase 22 (USP22), and suppress ubiquitin mediated degradation of Sirt1 protein by removing the conjugated polyubiquitin chains from Sirt1, XREF_BIBR leading to autophagy and chemoresistance."
30906827
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"HULC downregulates the abovementioned miRs and strongly upregulates USP22."
31608282
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"The investigation for the corresponding mechanism by which HULC stabilized Sirt1 revealed that HULC upregulated ubiquitin specific peptidase 22 (USP22), leading to the decrease of ubiquitin mediated degradation of Sirt1 protein by removing the conjugated polyubiquitin chains from Sirt1."
28166203