IndraLab

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USP22 deubiquitinates FBP1. 5 / 6
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"A previous study demonstrated that USP22 could inhibit the transcription of the cyclin-dependent kinase inhibitor 1A (p21) gene by deubiquitinating the transcriptional regulator fructose-1,6-bisphosphatase (FBP1) (5)."
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"Furthermore, USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator, FBP1 (5)."
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"18 USP22 also induced deubiquitination of FBP1, thereby promoting the progression of non-small cell lung cancer."
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"Empirical studies have demonstrated that USP22 can deubiquitylate nonhistone substrates as well (e.g., TRF1 and FBP) (14, 15)."
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"Moreover, USP22 knockdown upregulates the transcription of p21 by upregulating the ubiquitylation of FBP1."
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