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Statements

ABCA1 binds KCNMA1. 3 / 3
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"Addition of cholesterol to the PM by the MβCD–cholesterol complex dramatically restored SLO pore formation in ABCA1-expressing cells."
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"Finally, we examined other ABC proteins, which transport hydrophobic substrates including cholesterol, to demonstrate that ABCA1 inhibited SLO pore formation by moving cholesterol as a substrate (Fig.  xref )."
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"Although we have not directly measured asymmetric cholesterol distribution, we observed the suppression of SLO pore formation by ABCA1 not only in HEK293 but also in HeLa and BHK cells (data not shown), suggesting that this phenomenon is not cell type–specific."
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