IndraLab

Statements

USP47 increases the amount of SNAI1. 5 / 5
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"In HGC-27 cells, USP47 knockdown reduced Snai1 protein levels without affecting its mRNA expression (Figure 6D), indicating a posttranslational regulation of Snai1 by USP47."
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"Next, to determine whether USP47 promotes GC development through maintaining Snai1 levels, we induced the ectopic expression of Snai1 in USP47-depleted cells (Figure 6G and Supplemental Figure 14A)."
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"We found that the USP47 elevated the protein level of Snail without influencing the expression of its mRNA."
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"The inhibition of USP47 in combination with TGFβ2 treatment, decreases levels of SNAIL in the nucleus and cytoplasm as demonstrated by both high content screening and western blotting analysis."
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"Transient knockdown of USP47 in DLD-1 cells lowered the expression of Snail protein."
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