IndraLab

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TBX20 increases the amount of KCNH2. 3 / 3
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"Conversely, p.R311C Tbx20 did not increase KCNH2 expression in hiPSC-CMs, which led to decreased I hERG and increased APD."

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"In the presence of the mutated form, the protranscriptional effect of WT Tbx20 over KCNH2 was significantly reduced, suggesting that p.R311C Tbx20 did not enhance KCNH2 expression and impaired the eff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Tbx20 enhanced human KCNH2 gene minimal promoter activity and increased hERG channel protein expression in HL-1 cells."