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USP28 inhibits KDM1A. 4 / 4
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"In the human gastric cancer cell line HGC-27, the level of USP28 decreases in a dose-dependent manner of compound 19, leading to the degradation of the substrate LSD1 and total c-MYC through the prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37245535
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"Overexpression of HDAC5 significantly increases USP28 expression in cell lines and reduces USP28 polyubiquitination, supporting the idea that HDAC5 stabilizes LSD1 by enhancing its deubiquitinase prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37245535
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"To understand whether HDAC5 may stabilize LSD1 protein through upregulation of USP28 protein stability, a rescue study was carried out in MDA-MB-231 and MCF10A-CA1a cells using concurrent transfection of HDAC5 siRNA and USP28 expression plasmids, and showed that overexpression of USP28 completely blocked the destabilization of LSD1 by HDAC5 depletion (XREF_FIG, XREF_SUPPLEMENTARY)."
27212032
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"Overexpression of USP28 largely reversed HDAC5-knockdown-induced LSD1 protein degradation, suggesting HDAC5 positively regulates LSD1 by stabilizing USP28."
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