IndraLab

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USP3 deubiquitinates COL9A3. 4 / 4
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"These data suggest that USP3 promotes GC progression and metastasis by deubiquitinating COL9A3 and COL6A5."

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"Among them, SUZ12, a scaffolding component of the PRC2 complex, and COL9A3/COL6A5, collagen family members, were deubiquitinated and stabilized by USP3, which accounts for its role in promoting invasion and migration [21,22]."

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"The deubiquitination enzyme USP3, an essential mediator regulating oncogenic activity both in vitro and in vivo, can deubiquitinate COL9A3 and COL6A5 in gastric cancer cells."

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"Similarly, USP3 was reported to promote the gastric cancer progression and metastasis by deubiquitinating COL9A3 and COL6A5 [38]."