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USP25 inhibits NANOG. 2 / 2

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"Phosphorylation of mouse Usp21 at Ser539 by ERK1 in mESCs in response to differentiation stimuli blocked the interaction between Usp21 and Nanog, which consequently resulted in Nanog degradation and mESC differentiation (Jin et al., 2016)."

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"Depletion of endogenous USP21 by short hairpin RNA (shRNA) in mESC E14 cells reduced both the protein level (XREF_FIG) and half-life of Nanog, but not the half-life of other pluripotent factors such as Sox2, Oct4 and Klf4 (XREF_FIG)."

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USP25 inhibits NANOG. 2 / 2

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