IndraLab

Statements

USP48 deubiquitinates HMGA2. 4 / 4
| 4
reach
"Our findings collectively indicate that USP48 specifically regulates the stability of HMGA2 protein, rather than affecting HMGA2 mRNA levels.3.3 USP48 deubiquitinates HMGA2."
38572092
reach
"In contrast, Spautin-1 did not significantly impact the deubiquitination of HMGA2 by USP48, implying alternative mechanisms for its effect on HMGA2 stability (Fig. 7C)."
38572092
reach
"Our hypothesis posits that USP48 upregulation leads to deubiquitination and stabilization of HMGA2 protein, thereby impacting CRC cell invasion and metastasis."
38572092
reach
"Our findings demonstrate that USP48-WT significantly attenuates the ubiquitination of HMGA2, whereas USP48-C98S exerts no effect (Fig. 3A)."
38572092