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USP18 phosphorylates RELA. 3 / 3
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"TNFα induced serine 536 phosphorylation of p65, while the effect was attenuated by ISG15 overexpression and augmented by USP18 overexpression (Fig. 2A–D), suggesting that ISGylation impedes p65 phosphorylation."
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"Besides, we found that overexpression of USP18 again raised cGAS protein levels, and STING, TBK1, IRF3 and p65 phosphorylation levels in PR8-infected A549 cells, whereas these were reduced by interfer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Western blot analysis showed that interfering cGAS suppressed the increase of cGAS protein levels caused by overexpression of USP18 ( Fig. 5 A) and attenuated the induction of STING, TBK1, IRF3 and p6[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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