IndraLab

Statements

KCNMA1 activates MAPK. 4 / 4
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"Only LLO and SLO increased MAPK activation in combination with heat killed DeltacylE bacteria at sub-lytic concentrations (XREF_FIG)."
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"In addition, the overexpression of Slo in wt background also leads to an elevated dRaf level, resulting in BRAF/MAPK pathway activation."
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"Treatment of macrophages with heat killed bacteria and either LLO or SLO activates MAPK dependent secretion of IL-10 [XREF_BIBR], an anti-inflammatory cytokine, which suggests that the immune response to CDC intoxication is tempered by the presence of additional stimuli."
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"These observations confirmed the co-dependency of p-BRAF and KCNMA1 levels in HEK293T cells.It has been reported that the addition of KCl in cell culture medium depolarizes the membrane potential and activates the BRAF/MAPK pathway [65, 66]."
36763212