IndraLab

Statements

YOD1 inhibits NLRP3 inflammasome complex assembly. 6 / 6
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"Deficiency of YOD1 expression enhanced NLRP3 inflammasome activation and coagulation both in vitro and in vivo."
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"Collectively, these data indicated that YOD1 suppressed NLRP3 inflammasome activation in vitro.Next, we aimed to explore the biological effects of YOD1 on NLRP3 inflammasome activation in vivo."
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"These results indicated that YOD1 could attenuate NLRP3 inflammasome activation in vivo."
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"In our study, we showed that YOD1 interacted with NLRP3 and suppressed the NLRP3 inflammasome activation."
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"Mechanically, upon methicillin-resistant Staphylococcus aureus (MRSA) infection in macrophages, YOD1 interacted with NLRP3 to specifically remove its K33-linked ubiquitination, subsequently inhibiting NLRP3 inflammasome activation and coagulation."
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"These results demonstrated that YOD1 negatively regulated the NLRP3 inflammasome activation in a deubiquitinase activity-dependent manner and explored a novel function of YOD1.In summary, our study revealed one of the essential and original mechanisms by which YOD1 promoted sepsis-induced DIC, and proposed YOD1 as a priming therapeutic target for NLRP3-inflammasome dysregulation-mediated disorders."
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