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USP25 activates IRF3. 2 / 2

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"USP21 deficiency enhances intracellular IRF3 activation."

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"In addition, Lin et al. found that USP25, a deubiquitinating enzyme similar to USP5, promotes IRF3 and NF-κB activation and subsequent type I interferon and proinflammatory cytokine production after viral infection by stabilizing TRAF3 and TRAF6 [82]."

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USP25 activates IRF3. 2 / 2

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