IndraLab

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USP5 activates Neoplasm Invasiveness. 21 / 21
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"The experimental findings revealed that Degrasyn, an inhibitor of USP5, significantly impeded the proliferation, invasion and EMT progression of bladder cancer cells in vitro.However, the present study has certain limitations."
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"Additionally, USP5 knockdown markedly suppressed cell migration and invasion in UM1 and SCC9 48 h after transfection (Figure 5C–F), emphasizing USP5's role in enhancing the migratory and invasive behavior of HNSCC cells.2.5 Differential Gene Expression and Signatures Associated With USP5 Overexpression."
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"It was suggested that USP5 promoted EMT, invasion, and migration in NSCLC cells."
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"Results elucidated that USP5 contribute to cell invasion and metastasis in pancreatic cancer."
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"Meanwhile, USP5 was found to promote EMT, invasion, and migration of NSCLC cells, and its expression is correlated with EMT and metastasis in NSCLC tissues."
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"Here, we found that USP5 resulted in an increase in E-cadherin expression and decreases in N-cadherin and vimentin expression, inhibiting invasion and migration in NSCLC cells."
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"Knockdown of USP5 in DU145 cells significantly impaired both cell migration and invasion."
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"Moreover, the data revealed that USP5 silencing inhibited cell invasion and cancer stem–like cell properties; however, these effects were relieved after HDAC1 expression was increased (Figure 4g,h)."
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"13 Our results showed that USP5 silencing enhanced DDP sensitivity, induced cell apoptosis, and inhibited cell proliferation, invasion, and cancer cell stemness."
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"Further studies found that USP5 depletion reduces cell proliferation, invasion and the EMT in bladder cancer cells, and ectopic expression of Twist1 rescues the adverse effects of USP5 loss on cell invasion and the EMT."
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"It was suggested that USP5 promoted EMT , invasion , and migration in NSCLC cells ."
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"In contrast with USP5 overexpression, knockdown USP5 inhibited cell invasion and migration."
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"Knockdown of SLUG in USP5 + shSLUG group significantly inhibited the tumor cell invasiveness compared to the USP group in the Transwell assay (P<0.01; Fig. 5C)."
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"The aforementioned experimental results indicate that, in bladder cancer cells, USP5 enhances the proliferation, invasion and EMT process of tumor cells, mainly through SLUG."
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"Indeed, knockdown of USP5 expression significantly decreased cell motility and invasion in CL1-5 cells (Fig. 3D, F)."
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"In contrast, overexpression of USP5 promoted cell migration and invasion in A549 cells (Fig. 3E, G)."
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"Meanwhile , USP5 was found to promote EMT , invasion , and migration of NSCLC cells , and its expression is correlated with EMT and metastasis in NSCLC tissues ."
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"Here , we found that USP5 resulted in an increase in E-cadherin expression and decreases in N-cadherin and vimentin expression , inhibiting invasion and migration in NSCLC cells ."
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"USP5 promotes EMT and the invasion and migration of NSCLC cells."
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"Transwell assay and wound healing assay results also showed that knockdown of USP5 inhibited cell invasion and migration and overexpression of USP5 promoted cell invasion and migration."
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"These results suggest that pharmacological inhibition of USP5 significantly suppresses the proliferation, invasion and EMT process of bladder cancer cells."
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