IndraLab

"The interaction between USP35 and VEGFA was assessed by Co-IP assay and ubiquitination assay."

"The interaction between USP35 and VEGFA was assessed by Co-IP assay and ubiquitination assay."

"Furthermore, the stability of USP35 is regulated or maintained by fusin (FUS), USP35 interacts with vascular endothelial growth factor A (VEGFA), and FUS-stabilised USP35 promotes the growth, invasion, and angiogenesis of NSCLC cells by deubiquitinating VEGFA ( xref ). xref demonstrated that USP35 directly associates with the apoptosis-inhibiting protein BIRC3, modifying it via its deubiquitinating enzyme activity to prevent proteasomal degradation, by stabilising BIRC3, USP35 inhibits cisplatin-induced apoptosis in NSCLC cells, ultimately conferring resistance to cisplatin. xref indicate that in NSCLC, USP35 alleviates endoplasmic reticulum stress-induced apoptosis by stabilising ribosomal binding protein 1."

No evidence text available

No evidence text available