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USP8 deubiquitinates BACE1. 3 / 3
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ubibrowser
"The Endosome-associated Deubiquitinating Enzyme <span class="match term0">USP8</span> Regulates <span class="match term1">BACE1</span> Enzyme Ubiquitination and Degradation"
27302062
reach
"Furthermore, USP8 knockdown causes increased ubiquitination of BACE1 and degradation by accumulation of BACE1 in early endosomes and late lysosomes ( Yeates and Tesco, 2016 )."
34023421
signor
"Here, we report that RNAi-mediated depletion of USP8 reduced levels of both ectopically expressed and endogenous BACE1 in H4 human neuroglioma cells. Moreover, USP8 depletion increased BACE1 ubiquitination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decreased levels of BACE1 in the recycling endosomes."
27302062