IndraLab

Statements

Clobazam activates SCN1A. 5 / 5
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"Further work by this same group on mouse models has identified candidate genetic modifiers of sodium channel epilepsy in other ion channel genes, including a GABRA2 variant in an SCN1A knockout model,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In our studies, threshold temperature for hyperthermia induced seizures was elevated in Scn1a +/- mice treated with supratherapeutic levels of clobazam, while lower doses did not provide significant protection from hyperthermia induced seizures or premature death."
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"Following induction of a single, brief thermal seizure, we counted subsequent unprovoked GTCS in Scn1a +/- mice subchronically treated with valproic acid, clobazam, or stiripentol using doses that targeted the human therapeutic range."
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"Following induction of a single hyperthermic seizure, Scn1a +/- mice were subchronically treated with clobazam and stiripentol (160 mg per kg of chow and 4000 mg per kg of chow, respectively)."
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"Scn1a +/- mice treated with clobazam at doses corresponding to the human therapeutic range had an increased temperature threshold for hyperthermia induced seizures and reduced spontaneous seizure frequency compared to controls XREF_BIBR, XREF_BIBR."
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