IndraLab

Statements

USP35 activates Stomach Neoplasms. 9 / 9
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"We performed rescue experiments to determine whether USP35 promotes GC cell invasion and migration via Snail1."
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"6 B-E, Snail1 knockdown abolished USP35 overexpression-induced GC cell invasion and migration."
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"USP35 promotes GC invasion and migration, at least partially by regulating Snail1."
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"Transwell and scratch wound healing assays suggested that USP35 knockdown inhibited the invasion and migration of GC cells (Figs."
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"We also verified that USP35 promotes the proliferation and survival of GC cells, which is consistent with certain findings reported previously 30."
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"Furthermore, USP35 promoted the invasion and migration of GC cells depending on its DUB activity."
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"USP35 promotes GC metastasis in vivo."
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"These results suggest that USP35 relies on DUB activity to promote GC metastasis in vivo."
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"We found that overexpression of wild-type USP35 promoted GC cell invasion and migration in vitro and facilitated tumorigenesis and metastasis in vivo."
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