IndraLab

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Mutated nearby inhibits KCNH2. 1 / 1

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"A modulatory effect of the T618I mutation on I hERG inactivation is not entirely unexpected, given that mutation of the nearby S620 residue (to S620T) has been established to abolish hERG channel inactivation, although in contrast to the S620T mutation it is clear that the T618I mutation produces a more modest, partial attenuation of I hERG inactivation."

23300672

INDRA sources:

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IndraLab

Statements

Mutated nearby inhibits KCNH2. 1 / 1

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