IndraLab

Statements


USP37 activates MYC. 4 / 6
| 4

reach
"XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc."

reach
"The overexpression of USP37 markedly increases c-Myc abundance by blocking its degradation, whereas the depletion of USP37 promotes c-Myc degradation and reduces c-Myc levels."

reach
"Moreover, USP37 and USP22 have been shown to increase c-Myc stability via blockade of proteasomal degradation ( Kim et al., 2017 ; Pan et al., 2015 )."

reach
"Conversely, USP37 and USP29 promote tumorigenesis by stabilizing c-Myc through deubiquitination [22, 23]."