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USP29 activates cell population proliferation. 7 / 7
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"These data support the notion that USP29 promotes gastric cancer proliferation primarily through stabilization of AURKB.As deregulation of AURKB is observed in different tumors [4], to test whether USP29 is a global regulator of AURKB, we analyzed AURKB protein expression in neuroblastoma SKN-BE2, lung cancer A549 and colorectal cancer HCT116 cells with or without USP29 depletion."
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"Considering the important role of AURKB in controlling cell cycle, we reasoned that USP29 may promote gastric cancer cell proliferation by regulating cell cycle progression."
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"We next revealed that overexpression of USP29 in gastric cancer cell lines MGC-803 and SNU-216 significantly promoted the tumor cell proliferation (Fig. 1C and Supplementary Fig. 1C)."
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"After transfection of si-USP29, the proliferation of CRC cells was evaluated by the cell counting kit-8, colony formation and 5-ethynyl-2'-deoxyuridine assays, and we observed that depletion of USP29 inhibited the proliferation of CRC cells."
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"USP29 depletion produced a pronounced decrease in cell proliferation compared with the scrambled sgRNA control ( p = 0.0189 ) ( Figure 4B ) ."
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"Overexpression of USP29 stimulates the proliferation of colorectal cancer cell lines by regulating the activity of the cancer marker nuclear protein Ki67 [30]."
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"USP29 knockdown significantly decreased CRC cell proliferation in vitro."
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