IndraLab

Statements

TNFAIP3 inhibits lipopolysaccharide. 4 / 4
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"TNFAIP3 reduces pro inflammatory cytokines expression in LPS stimulated human NPCs."
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"However, TNFAIP3 overexpression in IECs attenuates LPS induced barrier loss in vivo and TNF induced decreases in TER in vitro."
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"siRNA mediated TNFAIP3 knockdown in MTX treated GM-MO significantly restored IL-6 secretion in response to LPS, as macrophages with lower A20 expression yielded significantly higher levels of LPS induced IL-6 (XREF_FIG)."
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"Other knockouts also caused expected phenotypes ; for example , moDCs with knockout of A20 ( TNFAIP3 ) , which inhibits LPS - and TNF-alpha-induced NF-kappaB signaling , secreted more TNF-alpha ( Figure 3c , Figure 3 - - figure supplement 5c ) ."
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