IndraLab

Statements

OTUD7B inhibits Dendritic Cells. 4 / 4
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"OTUD7b stabilizes TRAF2 by cleaving K48-linked polyubiquitin chains and prevents DC apoptosis."
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"However, combined pharmacological inhibition of RIPK1 activity (Nec1s) and apoptosis (zVAD-FMK) completely rescued survival of OTUD7b-deficient BMDC in vitro and in vivo indicating that OTUD7b inhibits RIPK1-independent and to a lesser extent RIPK1-dependent DC apoptosis [43]."
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"DC-specific OTUD7b prevents DC death and protects mice from ECM."
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"OTUD7b prevents DC death in human monocyte-derived DCs."
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