IndraLab

Statements

USP14 deubiquitinates DVL. 13 / 13
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"Effects of USP14 inhibitor IU1 confirmed that inhibition of USP14 by IU1 increases the K4 linked polyubiquitination of Dvl [XREF_BIBR]."
32486158
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"The inhibition of USP14 can also increase the degree of ubiquitination of Dvl and significantly inhibit the downstream of Wnt signal transduction [XREF_BIBR]."
32471496
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"Dvl is ubiquitinated by NEDL1, KLHL12, NEDD4L, Huwe1, Inversin, and ITCH and deubiquitinated by CYLD, USP9X, and USP14 (Miyazaki et al. 2004; Angers et al. 2006; Tauriello et al. 2010; Wei et al. 2012; Ding et al. 2013; Jung et al. 2013; de Groot et al. 2014; Nielsen et al. 2019)."
38383910
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"A recent report has shown that deubiquitination of disheveled (Dvl) by USP14 is required for Wnt signaling."
29326710
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"Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling."
23958854
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"As inhibition of Usp14 activity increased Dvl polyubiquitination, we examined whether knockdown of Usp14 has any effect on Wnt signaling."
23958854
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"To test direct deubiquitination of Dvl by Usp14, we performed a ubiquitin chain trimming assay using immunopurified Dvl-ubiquitin conjugates and recombinant Usp14 in a proteasome-free condition (XREF_FIG and XREF_SUPPLEMENTARY)."
23958854
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"Therefore, deubiquitination of Dvl by Usp14 may occur via their transient interaction during Wnt signal transduction."
23958854
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"These data suggest that deubiquitination of Dvl by Usp14 is necessary for the interaction between Fzd and Dvl."
23958854
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"As a lack of Dvl deubiquitination by Usp14 appears to attenuate Wnt signaling, we proposed that an elevated forward rate of ubiquitination, which will be counteracted by Usp14 activity, might be induced by Wnt3a CM treatment."
23958854
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"Contrary to its established mechanistic role, Usp14 mediates deubiquitination of Dvl without a requirement for its UBL domain."
23958854
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"Another research team discovered that USP14 deubiquitinated K63-linked polyubiquitin chains of Dvl, and USP14 inhibition could attenuate Wnt signal transduction [ 45 ]."
31676235
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"Inhibition of USP14 increases Dvl polyubiquitination and significantly impairs downstream Wnt signaling."
32486158