IndraLab

Statements

PKA inhibits KCNK2. 6 / 6
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"PKC and PKA phosphorylation inhibit TREK-1 channels downstream of G s protein-coupled receptor activation in vitro."
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"The inhibitory process is attributable to an increase of the intracellular cAMP concentration by riluzole that produces a protein kinase A-dependent inhibition of TREK-1."
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"The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation."
36620226
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"On the contrary, TREK-1 channel activity can be inhibited by G -coupled mGluR1/mGluR5 via PKC phosphorylation, G -coupled serotonin (5-HT4R) and β2 noradrenaline receptor (β2-AR) via PKA-dependent phosphorylation [4]."
31728930
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"These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH, NPS-ACTH, forskolin, and 8-pCPT-2′-O-Me-cAMP also inhibit these K + channels by a PKA-independent signaling pathway."
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"TREK-1 activation, unlike TRAAK, is reversed by protein kinase A and protein kinase C stimulation [18,19 **,20,24 **,27,30 **]."
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