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PKA inhibits KCNK2. 12 / 12
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"PKC and PKA phosphorylation inhibit TREK-1 channels downstream of G s protein-coupled receptor activation in vitro."
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"The inhibitory process is attributable to an increase of the intracellular cAMP concentration by riluzole that produces a protein kinase A-dependent inhibition of TREK-1."
10779373
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"These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH, NPS-ACTH, forskolin, and 8-pCPT-2′-O-Me-cAMP also inhibit these K + channels by a PKA-independent signaling pathway."
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"The complexity of multiple cAMP‐dependent mechanisms regulating TREK‐1 currents is even evident in model systems such as Xenopus oocytes, which display PKA‐dependent inhibition of TREK‐1 and express endogenous POPDC1 (Lopes et al, 2007; Claußen et al, 2015; Wiedmann et al, 2021)."
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"This pronounced G s - or PKA-mediated TREK-1 inhibition would result in the inhibition of stretch-activated SAK currents under sympathetic stimulation or stress."
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"However, two independent studies concur, that in rat corticotrope cells K + channels inhibited by PKA and insensitive to tetraethylammonium as well as apamin, such as HERG or TREK-1 are likely to unde[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22085559
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"As PKA dependent phosphorylation is known to inhibit the TREK-1 channel [27], it is possible that inhibition of the PKA signaling potentiates the THIK-1 channel."
37099539
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"It has previously been found that PKA and PKC inhibit TREK channels via direct phosphorylation xref , xref , xref , xref , and in this study we report that calcineurin mediates the opposite, activating effect."
41457157
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"Phosphorylation-dependent inhibition of TREK-1 by protein kinase A and C (PKA and PKC) was previously reported, and serine 300 and 333 were identified as the regulatory residues in the proximal part of the long intracellular C-terminal region of the channel xref ."
41457157
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"The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation."
36620226
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"On the contrary, TREK-1 channel activity can be inhibited by G -coupled mGluR1/mGluR5 via PKC phosphorylation, G -coupled serotonin (5-HT4R) and β2 noradrenaline receptor (β2-AR) via PKA-dependent phosphorylation [4]."
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"TREK-1 activation, unlike TRAAK, is reversed by protein kinase A and protein kinase C stimulation [18,19 **,20,24 **,27,30 **]."
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