IndraLab

Statements

UCHL5 activates CTNNB1. 7 / 7
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"The ability of UCHL5 to promote metastasis can be increased by using β-catenin inhibitors or decreased by using β-catenin (Fig. 5B and D)."
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"Additionally, UCHL5 knockdown caused a significant reduction in β-catenin and c-Myc levels, key components of the Wnt/β-catenin signaling pathway, suggesting that UCHL5 may stabilize β-catenin and facilitate Wnt/β-catenin signaling (Fig. 9G)."
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"Proteasomal deubiquitinase UCH37 inhibits degradation of beta-catenin and promotes cell proliferation and motility."
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"The presence of UCHL5 up regulates and activates β-catenin, thereby promoting the proliferation of endometrial cancer [21, 31]."
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"As shown in Figure 5A , UCHL5 knockdown decreased the expression of beta-catenin ."
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"UCHL5 Activated Wnt/beta-Catenin Signaling and Affected the Expression of Its Target Genes."
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"UCHL5 reduces beta-catenin degradation through deubiquitination."
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