IndraLab

Statements

THBD binds FN1. 32 / 32
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"TM co-localized with fibronectin on the tumor blood vessels, implying that fibronectin molecules bind to endothelial TM during tumor angiogenesis."
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"Given our previous results that the lectin like domain of TM binds to fibronectin [XREF_BIBR], we were surprised to find that CS deficiency, not the lectin like domain deletion, eliminates VSMCs adhesion and migration on fibronectin (Additional file 1 : Figure S2 and Fig."
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"The interaction between TM and fibronectin in tumor blood vessels was also validated by the proximity ligation assay."
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"We confirmed the binding of fibronectin to human breast cancer derived cell lines under two conditions (in the presence of Mg 2+ / Ca 2+ or Mg 2+) in order to examine whether the presence or absence of Ca 2+ is important for TM binding to fibronectin."
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"TM binds fibronectin (XREF_FIG) and is intimately involved in breast cancer invasion and metastasis [XREF_BIBR]."
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"Therefore, sufficient exogenously administered doses of TM might bind fibronectin on the vascular endothelium and inhibit the binding of tumor cell beta1 integrin to fibronectin."
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"Based on the result that the TM lectin-like domain binds predominantly to fibronectin, we further explored the effect of TM on cell adhesion to fibronectin."
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"The thrombomodulin–fibronectin interaction occurs on tumour blood vessels in murine melanoma suggesting that this interplay may serve as a putative target for antiangiogenic therapy, although an in‐depth understanding of this interaction in healthy tissues would first need to be considered."
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"Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin."
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"The interaction between TM and fibronectin in tumor blood vessels was also validated by the proximity ligation assay."
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"Based on the result that the TM lectin like domain binds predominantly to fibronectin, we further explored the effect of TM on cell adhesion to fibronectin."
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"This observation implies that TM interacts with fibronectin to extend and maintain the endothelial tube structures."
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"To further confirm the TM-fibronectin interaction during tumor angiogenesis, we performed the PLA using Duolink In Situ reagents."
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"This observation implies that TM interacts with fibronectin to extend and maintain the endothelial tube structures."
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"TM is expressed on tumor blood vessels and binds to fibronectin during tumor angiogenesis."
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"TM-fibronectin interactions were visualized as red fluorescent spots that were present on the tumor blood vessel (Figure xref , arrows in the enlarged image)."
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"These results indicate that TM is expressed on the tumor vasculature and interacts with fibronectin during tumor angiogenesis."
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"Furthermore, shared binding partners amongst the group XIV proteins support their homology; CD248, CD93, and CLEC14a bind to endothelial extracellular matrix (ECM) protein multimerin-2 (MMRN2), although at different regions of their extracellular domains; TM and CD248 bind ECM glycoprotein fibronectin while TM and CLEC14a are known to both bind heat shock protein 70-1 (HSP70-1)."
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"The lectin-like domain of thrombomodulin was found to be essential for the binding of the extracellular domain of thrombomodulin to fibronectin."
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"We demonstrated here that PMA induces expression of TM, which can bind to fibronectin to increase cell adhesion and FAK activation."
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"The Lectin-Like Extracellular Domain of TM Binds Fibronectin."
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"To elucidate which of the three extracellular domains (lectin-like domain (domain 1; D1), epidermal growth factor (EGF)-like domain (domain 2; D2), and serine-threonine-rich domain (domain 3; D3)) of TM binds fibronectin, we fused the extracellular domain with human IgG Fc protein to create the TMD123-Fc protein ( xref )."
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"Subsequently, we observed that fibronectin bound to the TM protein containing the lectin-like domain ( p < 0.05) ( xref ), whereas TMD23-Fc did not bind fibronectin."
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"This mechanism adds novel depth to the previously demonstrated understanding that TM binding fibronectin promotes tumor cell adhesion, migration, and angiogenesis [77]."
38468017
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"We demonstrated here that PMA induces expression of TM, which can bind to fibronectin to increase cell adhesion and FAK activation."
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"We confirmed the binding of fibronectin to human breast cancer-derived cell lines under two conditions (in the presence of Mg 2+ /Ca 2+ or Mg 2+ ) in order to examine whether the presence or absence of Ca 2+ is important for TM binding to fibronectin."
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"TM co-localized with fibronectin on the tumor blood vessels (Figure xref , arrows), implying that fibronectin molecules bind to endothelial TM during tumor angiogenesis."
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"The lectin-like domain of TM binds the ECM protein fibronectin; however, it remains unknown whether TM inhibits the adhesion of fibronectin to cancer cell integrins [ xref ]."
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"TM binds fibronectin ( xref ) and is intimately involved in breast cancer invasion and metastasis [ xref ]."
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"The Lectin Like Extracellular Domain of TM Binds Fibronectin."
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"In addition, we used the PLA to show the TM-fibronectin interactions on the tumor blood vessels (Figure xref , arrows in the enlarged area)."
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"To elucidate which of the three extracellular domains (lectin like domain (domain 1; D1), epidermal growth factor (EGF)-like domain (domain 2; D2), and serine-threonine-rich domain (domain 3; D3)) of TM binds fibronectin, we fused the extracellular domain with human IgG Fc protein to create the TMD123-Fc protein (XREF_FIG)."
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