IndraLab

Statements

THBD binds FN1. 17 / 17
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"The thrombomodulin–fibronectin interaction occurs on tumour blood vessels in murine melanoma suggesting that this interplay may serve as a putative target for antiangiogenic therapy, although an in‐depth understanding of this interaction in healthy tissues would first need to be considered."
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"To elucidate which of the three extracellular domains (lectin-like domain (domain 1; D1), epidermal growth factor (EGF)-like domain (domain 2; D2), and serine-threonine-rich domain (domain 3; D3)) of TM binds fibronectin, we fused the extracellular domain with human IgG Fc protein to create the TMD123-Fc protein ( xref )."
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"To elucidate which of the three extracellular domains (lectin like domain (domain 1; D1), epidermal growth factor (EGF)-like domain (domain 2; D2), and serine-threonine-rich domain (domain 3; D3)) of TM binds fibronectin, we fused the extracellular domain with human IgG Fc protein to create the TMD123-Fc protein (XREF_FIG)."
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"To better understand what changes occurred from Dex treatment that affect the Fn binding capacity of the exosomes and perhaps account for the ECM accumulation in steroid-induced glaucoma, we investigated the binding of Fn to TM exosomes in vitro."
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"We confirmed the binding of fibronectin to human breast cancer derived cell lines under two conditions (in the presence of Mg 2+ / Ca 2+ or Mg 2+) in order to examine whether the presence or absence of Ca 2+ is important for TM binding to fibronectin."
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"The Lectin-Like Extracellular Domain of TM Binds Fibronectin."
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"To test whether a receptor for heparan sulfate exists and mediates Fn binding on TM exosomes, we incubated conditioned media from TM cell monolayers with increasing concentrations of heparan sulfate, isolated exosomes from the conditioned media and probed for Fn."
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"The lectin-like domain of thrombomodulin was found to be essential for the binding of the extracellular domain of thrombomodulin to fibronectin."
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"Since binding of Fn to TM exosomes is mediated through heparin/heparan sulfate, we conclude that a reduction in heparin/heparan sulfate binding proteins likely contributes to decreased Fn binding in exosomes from Dex treated explants.Fn-bound exosomes are reported to mediate a number of cell-matrix interactions including migration and invasion [18, 20], two processes dependent on podosomes/invadopodia and ECM digestion [10]."
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"We confirmed the binding of fibronectin to human breast cancer-derived cell lines under two conditions (in the presence of Mg 2+ /Ca 2+ or Mg 2+ ) in order to examine whether the presence or absence of Ca 2+ is important for TM binding to fibronectin."
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"TM binds fibronectin (XREF_FIG) and is intimately involved in breast cancer invasion and metastasis [XREF_BIBR]."
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"TM binds fibronectin ( xref ) and is intimately involved in breast cancer invasion and metastasis [ xref ]."
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"Therefore, sufficient exogenously administered doses of TM might bind fibronectin on the vascular endothelium and inhibit the binding of tumor cell beta1 integrin to fibronectin."
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"Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin."
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"The Lectin Like Extracellular Domain of TM Binds Fibronectin."
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"The lectin-like domain of TM binds the ECM protein fibronectin; however, it remains unknown whether TM inhibits the adhesion of fibronectin to cancer cell integrins [ xref ]."
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"Subsequently, we observed that fibronectin bound to the TM protein containing the lectin-like domain ( p < 0.05) ( xref ), whereas TMD23-Fc did not bind fibronectin."
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