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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mexiletine activates SCN5A-N406K. 2 / 2

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"We discovered mexiletine could elevate the reduced peak sodium current and inhibit the increased late sodium current at the same time, and partially restore the function of SCN5A N406K mutant channel with a mixed biophysical phenotype."

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"The decrease in cell surface expression caused by SCN5A N406K mutants was reversed by mexiletine, further supporting the hypothesis that mexiletine could increase the peak I Na of SCN5A N406K mutation through rescuing the trafficking defect of SCN5A-N406K."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...