IndraLab

Statements

USP13 activates MTOR. 8 / 8
| 8
reach
"To confirm USP13 accelerates the proliferation of HCC cells through regulating PRPF6‐AKT‐mTOR signalling, we performed the rescue experiments by silencing PRPF6 in USP13 up‐regulated cells."
40208227
reach
"It was found that knock down of PRPF6 effectively inhibited the cell proliferation and also reduced the expressions of p‐AKT and p‐mTOR induced by overexpression of USP13 (Figures 7A,B)."
40208227
reach
"These results suggest that the USP13‐PRPF6 axis promotes HCC cell proliferation by regulating AKT‐mTOR signalling.3.6 USP13 Expression Is Correlated With PRPF6 in Human HCC Tissues."
40208227
reach
"Overall, USP13 facilitates the malignant progression of HCC cells through the upregulation of WWP1.Thus, we concluded that USP13 stabilized WWP1, and then activated the Akt/mTOR pathway."
40319251
reach
"Further experimental results confirmed that the USP13‐PRPF6 axis promoted the proliferation of HCC cells by modulating the AKT‐mTOR signalling pathway.In conclusion, we have demonstrated that USP13 can decrease the K48/63‐linked polyubiquitination of PRPF6, thereby stabilising this protein and promoting HCC cell proliferation via regulation of the AKT‐mTOR pathway (Figure 8C)."
40208227
reach
"Moreover, USP13 stabilized WWP1 by removing the K29- and K48-linked polyubiquitination chains from WWP1 and then activated the Akt/mTOR pathway in HCC."
40319251
reach
"By acting as an oncogene, USP13 affects HCC malignant progression through the WWP1-mediated Akt/mTOR pathway."
40319251
reach
"Importantly, USP13 modulated the AKT‐mTOR signalling pathway in a manner analogous to PRPF6 (Figures 6D,E)."
40208227