IndraLab

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CRISPR inhibits BAP1. 5 / 5
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"CRISPR/Cas9-mediated knockout of BAP1.."
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"We also identified an association of clinical BAP1 mutations with high B7H4/3 expression, and validated it as a causal relationship between CRISPR-mediated BAP1 loss and B7H4 upregulation in iCCA cell line models."
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"B. Artegiani et al. described that liver organoids with four common cholangiocarcinoma mutations (TP53, PTEN, SMAD4, and NF1) gained malignancy after loss-of-function of BAP1 by CRISPR/Cas9, because BAP1 could control the expression of junctional and cytoskeleton components by regulating chromatin accessibility (44)."
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"Artegiani et al. found that after loss-of-function of BAP1 by CRISPR/Cas9 in normal human cholangiocyte organoids, the cells became more motile and fused with other organoids, features that resemble the metastatic invasion of cancer."
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"CRISPR/Cas9-mediated knockout of BAP1 in PANC1 murine pancreatic cancer cells and HEK 293 T cells induced chromosome abnormalities, including chromosome breaks, shattering and aneuploidy, and these effects were exacerbated by cell exposure to IR ."
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