IndraLab

Statements

TRAF2 binds CYLD and IKBKG. 3 / 3
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sparser
"Mechanistically, CYLD binds to NEMO and TRAF2 and reverses non-K48-linked polyubiquitination of TRAF2, thereby blocking TRAF2-mediated activation of the IKK complex [ xref - xref ] ( xref )."
27844253
sparser
"The direct interaction of CYLD with both TRAF2 and NEMO is facilitated by N-terminal protein-protein interaction domains and contributes to its activity toward these substrates ( Kovalenko et al., 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
sparser
"Interestingly, CYLD interacts with NEMO (IKKγ; references xref – xref ) and TRAF2 ( xref , xref ), both of which are recruited to the TNF receptor upon ligand binding."
14676304