IndraLab

Statements

USP5 inhibits apoptotic process. 19 / 19
| 2 17
reach
"Inhibition of USP5 protein induces apoptosis of MM cells by reducing c-Maf stability, enhancing MM sensitivity to thiabendazole [20, 22]."
40274624
eidos
"USP5 deficiency also induces DNA damage , cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells ( 51 , 53 ) ."
33643919
reach
"USP5 expression also inhibits apoptosis induced by histidine-rich protein (Hpn), a cytoplasmic protein derived from Helicobacter pylori that can induce cell apoptosis [ 39 ]."
38049041
reach
"Furthermore, BRAF (a melanoma mutation gene) activation of USP5 can inhibit cell cycle checkpoint control and cell apoptosis by blocking p53 and FAS induction [ 40 ]."
38049041
reach
"Therefore, usp5 suppression of apoptosis is necessary for the differentiation of photoreceptors."
24643212
reach
"Second, loss of usp5 activates apoptosis and the JNK pathway."
24643212
reach
"13 Our results showed that USP5 silencing enhanced DDP sensitivity, induced cell apoptosis, and inhibited cell proliferation, invasion, and cancer cell stemness."
39582290
reach
"Loss of usp5 activates apoptosis and the JNK pathway."
24643212
eidos
"In the present study , our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8 , which were initially showed to induce apoptosis in various cancers ."
33319070
reach
"Furthermore, silencing of USP5 causes cell cycle arrest in the G1/S phase, which is accompanied by accumulated DNA damage and increased apoptosis in PDAC cells [ 45 ]."
31756387
reach
"In HCC, the upregulation of USP5 is associated with tumor growth, drug resistance, and reduced apoptosis, suggesting its role in carcinogenesis and as a potential target for HCC therapy [85]."
38927085
reach
"Usp5 knockdown suppressed cell viability and induced apoptosis in HCC cells."
28881591
reach
"Suppression of USP5 activates the tumour suppressor TP53, [10] restores cell cycle check point control and induces apoptosis [11] ."
37060785
reach
"In addition, it had been found that silencing of USP5 may increase apoptosis and DNA damage to suppress the progression of PAAD ."
37268697
reach
"Our study showed that Usp5 knockdown induced cell cycle arrest and apoptosis, at least partially associated with p53 expression."
28881591
reach
"USP5 knockdown leads to DNA damage, cell cycle arrest and apoptosis in PDAC cells."
29029505
reach
"Therefore, we analyzed the effect of USP5 knockdown on the irradiation-induced apoptosis of NPC cells."
39897046
reach
"Flow cytometric analysis showed that USP5 knockdown significantly increased apoptosis of NPC cells in both 4Gy IR and no irradiation groups, but the promotion effect of USP5 knockdown on cell apoptosis was stronger in 4Gy IR group than in no irradiation group, and EphA2 overexpression recovered the apoptosis of NPC cells with USP5 knockdown in both groups (Fig. 4B)."
39897046
reach
"Moreover, inhibiting USP5 by genetic shRNA or small molecule inhibitors such as WP1130 leads to MM cell apoptosis [XREF_BIBR]."
31197245