IndraLab

Statements

USP5 inhibits apoptotic process. 10 / 10
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"Loss of usp5 activates apoptosis and the JNK pathway."
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"Usp5 knockdown suppressed cell viability and induced apoptosis in HCC cells."
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"In the present study , our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8 , which were initially showed to induce apoptosis in various cancers ."
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"Moreover, inhibiting USP5 by genetic shRNA or small molecule inhibitors such as WP1130 leads to MM cell apoptosis [8]."
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"Therefore, usp5 suppression of apoptosis is necessary for the differentiation of photoreceptors."
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"Second, loss of usp5 activates apoptosis and the JNK pathway."
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"USP5 knockdown leads to DNA damage, cell cycle arrest and apoptosis in PDAC cells."
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"USP5 deficiency also induces DNA damage , cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells ( 51 , 53 ) ."
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"Moreover, inhibiting USP5 by genetic shRNA or small molecule inhibitors such as WP1130 leads to MM cell apoptosis [XREF_BIBR]."
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"Our study showed that Usp5 knockdown induced cell cycle arrest and apoptosis, at least partially associated with p53 expression."
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