IndraLab

Statements

USP47 activates BCR. 4 / 4
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"In IM-resistant CML, pharmacological inhibition of ubiquitin-specific peptidase 47 (USP47) with P22077 reduces the percentage of CD34 CD38 cells in secondary BM transplantation and inhibits colony-forming activity of CD34 cells from IM-resistant CML patients while sparing normal CD34 cells [234]."
36009388
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"The knockout of USP47 or using P22077 also significantly impaired BCR-ABL and BCR-ABL -induced CML in mice and reduced the number of CML stem/progenitor cells."
38947742
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"USP47 knockdown significantly inhibited both BCR-ABL-induced CML in mice and BCR-ABL -induced CML, which are known to confer Imatinib and second-generation TKI resistance ."
37740002
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"USP47 knockout significantly inhibited BCR-ABL and BCR-ABL -induced mouse CML with reduced of LIN Sca1 c-kit CML stem cells/progenitor cells."
34604226