IndraLab

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USP18 activates cell population proliferation. 21 / 23
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"For example, ISG15/USP18 promotes the proliferation and inhibits the apoptosis of HBV-associated HCC cells [72]."
31146743
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"This study showed that USP18 can promote the proliferation of colorectal cancer cells and might be a potential biomarker for the diagnosis of CRC."
34042164
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"Simultaneously, CCK8 and EdU assays showed that the reduced proliferation induced by USP18 knockdown in BxPC-3 cells was partly abolished by the introduction of c-Myc (XREF_FIG - XREF_FIG)."
33051403
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"However, USP18 silencing blocked the proliferation and migration induced by FTO."
33461172
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"In conclusion, USP18 promoted the proliferation and migration of ovarian cancer cells by activating AKT/mTOR signaling."
35696596
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"Silencing USP18 in SiHa and Caski cervical cancer cell lines inhibited cell proliferation, induced apoptosis, and promoted cleaved caspase-3 expression."
32770981
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"Overall, these results suggested that USP18 promotes pancreatic cancer cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis."
33051403
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"USP18 and FTO promote BLCA cell proliferation and migration."
33461172
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"A study has indicated that USP18 contributes to controlling carcinogenesis, as loss of USP18 function increases apoptosis and decreases cell proliferation by destabilization of the cyclin D1 protein 22.It remains, however, unclear so far whether the EFP, HERC5 and USP18 genes contribute to tumourigenesis through ISG15/ISGylation or other mechanisms."
32132870
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"The results showed that knockdown of USP18 reduced cell viability and ovarian cancer proliferation."
35696596
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"In present study, our data indicated that knockdown of USP18 could inhibit cell proliferation and induce cell cycle arrest in the G1 phase in HCC cells."
28709980
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"Furthermore, knockdown of USP18 significantly suppressed tumour cell proliferation in vitro and tumour growth in vivo, whereas overexpression of USP18 promoted HCC cells growth."
28709980
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"USP18 positively regulates cell proliferation."
23291318
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"Wound healing assays suggested that USP18 promoted the proliferation of CRC cells."
34042164
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"USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway."
35696596
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"We further demonstrated that overexpression of USP18 modestly enhances proliferation of kidney cells and Usp18 is overexpressed in a mouse model of Wilms tumor."
23291318
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"This suggests that USP18 positively modulates cell proliferation."
23291318
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"USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway."
32770981
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"Loss of USP18 inhibits cell proliferation and increases apoptosis [XREF_BIBR]."
29543760
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"Overexpression of Usp18 in HEK293 or M15 cells promoted cell proliferation, consistent with the model that the increased expression of Usp18 following Wt1 mutation is a critical step in tumorigenesis."
23291318
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"In contrast, overexpression of USP18 promotes the proliferation of HepG2.2.15 cells (P < 0.05; Fig. 2 G and H)."
28709980