IndraLab

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USP18 activates cell population proliferation. 45 / 47
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"Furthermore, silencing USP18 attenuated HNSC cell proliferation, invasion, and migration, while overexpression of USP18 exerted converse effects."
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"Knockdown of USP18 expression suppressed the proliferation capacity and colony formation of glioma cells."
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"Subsequently, we validated that USP18 modulated PLK1 to activate the mTORC1 pathway, thereby facilitating HNSC cell proliferation, invasion, and migration."
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"Silencing USP18 in SiHa and Caski cervical cancer cell lines inhibited cell proliferation, induced apoptosis, and promoted cleaved caspase-3 expression."
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"In present study, our data indicated that knockdown of USP18 could inhibit cell proliferation and induce cell cycle arrest in the G1 phase in HCC cells."
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"Overall, these results suggested that USP18 promotes pancreatic cancer cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis."
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"For instance, USP18 could promote the malignant proliferation of glioblastoma by stabilizing Twist1 protein [ 18 ]."
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"In breast cancer, USP18 promotes proliferation and cell cycle progression via activating AKT/Skp2 and elevating EGFR [ 20 ]."
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"Simultaneously, CCK8 and EdU assays showed that the reduced proliferation induced by USP18 knockdown in BxPC-3 cells was partly abolished by the introduction of c-Myc (XREF_FIG - XREF_FIG)."
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"Additionally, knockdown of USP18 inhibited the proliferation of HCC cells and induced G1 cell cycle arrest and early apoptosis."
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"Moreover, we observed that suppression of USP18 in ependymal cells treated with IFN significantly increased cell death, including pyroptosis, and decreased proliferation."
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"USP18 promoted HCC cell proliferation by inhibiting apoptosis."
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"Next, a cell viability assay was performed to test whether suppression of USP18 significantly inhibited cell proliferation in both Huh7 and SMMC7721 cells (Fig. 1e)."
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"Overexpression of USP18 significantly promoted cell proliferation in both cell types (Fig. 1f)."
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"The CCK-8 assay showed that the overexpression of USP18 significantly promoted gEECs proliferation at 96 h ( p < 0.05, Fig. 2 A)."
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"These results suggest that USP18 can promote the continuous proliferation of HCC cells by affecting apoptosis."
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"The results showed that knockdown of USP18 reduced cell viability and ovarian cancer proliferation."
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"In agreement with this study, Zhang found that high expression of USP18 promoted the proliferation of rectal cancer cells [ 37 ]."
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"The results of this study showed that USP18 promotes the proliferation of endometrial epithelial cells."
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"In conclusion, USP18 promoted the proliferation and migration of ovarian cancer cells by activating AKT/mTOR signaling."
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"Loss of USP18 inhibits cell proliferation and increases apoptosis [XREF_BIBR]."
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"Wound healing assays suggested that USP18 promoted the proliferation of CRC cells."
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"This study showed that USP18 can promote the proliferation of colorectal cancer cells and might be a potential biomarker for the diagnosis of CRC."
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"USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway."
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"Moreover, recent studies have shown that deletion of USP18 reduces tumor cell proliferation, migration, and invasion [93]."
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"Previously, USP18 was reported to regulate apoptosis by regulating the stability of 14-3-3ζ in lung cancer cells and to promote the proliferation and migration of ovarian cancer cells by activating protein kinase B/mammalian target of rapamycin (AKT/mTOR) signaling ."
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"Overexpression of Usp18 in HEK293 or M15 cells promoted cell proliferation, consistent with the model that the increased expression of Usp18 following Wt1 mutation is a critical step in tumorigenesis."
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"USP18 positively regulates cell proliferation."
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"This suggests that USP18 positively modulates cell proliferation."
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"For example, ISG15/USP18 promotes the proliferation and inhibits the apoptosis of HBV-associated HCC cells [72]."
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"We further demonstrated that overexpression of USP18 modestly enhances proliferation of kidney cells and Usp18 is overexpressed in a mouse model of Wilms tumor."
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"In summary, USP18 knockdown inhibited proliferation, migration but enhanced apoptosis and ferroptosis in LUAD cells."
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"A study has indicated that USP18 contributes to controlling carcinogenesis, as loss of USP18 function increases apoptosis and decreases cell proliferation by destabilization of the cyclin D1 protein 22.It remains, however, unclear so far whether the EFP, HERC5 and USP18 genes contribute to tumourigenesis through ISG15/ISGylation or other mechanisms."
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"USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway."
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"Overexpression of USP18 promotes cervical cancer cell proliferation and attenuates apoptosis by activating the PI3K/AKT signaling pathway [ 9 ]."
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"showed that USP18 contributed to proliferation and reduced apoptosis in cervical cancer [27]."
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"Moreover, USP18 upregulation significantly accelerates the proliferation and migration of bladder cancer cells by enhancing the FTO/PYCR1 pathway [ 10 ]."
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"Furthermore, Silencing USP18 inhibits the proliferation and increases apoptosis of pancreatic cancer cells [ 11 ]."
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"Silencing USP18 suppressed COAD cell proliferation and invasion via destabilizing extracellular signal-regulated kinase (ERK) protein and suppressing ERK downstream pathways."
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"In conclusion, the present study demonstrated that knockdown of USP18 expression inhibited the proliferation of glioma cells, which may be mediated by the effect of USP18 on the IFN-I response."
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"USP18 and FTO promote BLCA cell proliferation and migration."
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"Also, in muscle cells, USP18 depletion leads to reduced proliferation."
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"However, USP18 silencing blocked the proliferation and migration induced by FTO."
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"Collectively, these results indicated that USP18 knockdown inhibited the proliferation and induced the apoptosis of glioma cells."
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"In contrast, overexpression of USP18 promotes the proliferation of HepG2.2.15 cells (P < 0.05; Fig. 2 G and H)."
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