IndraLab

Statements

USP37 activates USP37. 4 / 4
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"Mechanistically, CDK2 phosphorylates USP37 at serine 628 (Ser ) and then activates USP37 deubiquitinase activity."
37955924
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"Silencing of USP37 expression induced MET including upregulated E-cadherin expression and downregulated N-cadherin expression, while PM reversed MET in silenced USP37 cells."
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"Ambiguously, the transcription of USP37 is suppressed in medulloblastoma cells through the activity of RE1 silencing transcription factor to prevent the USP37 mediated stabilization of the cyclin dependent kinase inhibitor p27, which is known to act as a negative regulator of cell cycle XREF_BIBR."
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"To further investigate whether USP37 phosphorylation is able to activate USP37, a two-step assay was carried out."
34606619