IndraLab

Statements

OTUD5 inhibits inflammatory response. 5 / 5
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"Specifically, podocyte-specific overexpression of OTUD5 potentially serves as a feasible strategy to inhibit podocyte inflammation by down-regulating TAK1 activity, ultimately controlling the progression of DKD."
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"Lipid accumulation and inflammation were exacerbated by Otud5 knockdown but attenuated by Otud5 overexpression under PAOA treatment."
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"OTUD5 overexpression in primary hepatocytes inhibited PAOA-induced hepatocyte lipid accumulation and inflammation (Figure 5A–D)."
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"Therefore, we hypothesize that OTUD5 negatively regulates inflammation and injury through deubiquitinating TAK1 in podocytes.We confirmed the endogenous interaction between OTUD5 and TAK1 in podocytes using a Co-immunoprecipitation (co-IP) assay (Fig. 4c)."
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"Macrophage-specific ablation of DUBA attenuated MDP-induced systematic inflammation and liver injury in mice."
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